On-Cartridge Drying

For the accelerated production of our 18F-peptides

For this purpose, SCINTOMICS exploits two unique ¹⁸F-labeling technologies that avoid time-consuming azeotropic drying of ¹⁸F-fluoride. While both techniques are based on ´on-cartridge drying´, they differ in the basicity of the final labeling reaction. Recently, an improved drying method has been developed that allow label even complex peptides with ¹⁸F-fluorine by isotopic exchange that are unstable under basic conditions (Method A). Similar to the established ´Munich Method´ (Method B), this novel technique result in a rapid incorporation of ¹⁸F-fluoride into peptides at room temperature within 5 min or less and allow for the production of ¹⁸F-peptides and peptide-like ligands on a >100GBq scale within about 15 minutes EOB under GMP conditions.